Sitagliptin works to competitively inhibit the enzyme dipeptidyl peptidase 4 (DPP-4). This enzyme breaks down the incretins GLP-1 and GIP,gastrointestinal hormones released in response to a meal. By preventing GLP-1 and GIP inactivation, they are able to increase the secretion of insulin and suppress the release of glucagon by the alpha cells of the pancreas.
This drives blood glucose levels towards normal. As the blood glucose level approaches normal, the amounts of insulin released and glucagon suppressed diminishes, thus tending to prevent an “overshoot” and subsequent low blood sugar (hypoglycemia) which is seen with some other oral hypoglycemic agents.
Producte name: Sitagliptin
Cas : 486460-32-6
Molecular Formula: C16H15F6N5O
Molecular Weight: 523.32
Appearance: White crystalline powder
|Packaging details:||25kg/drum with double plastic bags inside; packed in a cardboard drum or fiber HDPE drum.|
|Storage:||Stored in a clean, cool, dry area; keep away from moisture and strong, direct light/heat|
|Shelf Life:||5 years if sealed and store away from direct sun light.|
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